Topiramate, sold under the brand name Topamax among others, is a medication used to treat epilepsy and prevent migraines. It has also been used in alcohol dependence. For epilepsy this includes with generalized or focal seizures. It is taken by mouth. Making Sense of Antiepileptic Drugs in 2007 Thomas K. Koch, MD Ortho McNeil Pharmaceuticals Speakers Bureau Abbott Laboratories Speakers Bureau Cytochrome P450 3A4 (abbreviated CYP3A4) (EC 1.14.13.97) is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes small foreign organic molecules (xenobiotics), such as toxins or drugs, so that they can be removed from the body. If emergency contraception is required for women and girls taking enzyme-inducing anti-epileptic drugs (AEDs), the type and dose of emergency contraception should be in line with the SPC and current edition of the BNF (1) Clinical experience with topiramate dosing and serum levels in patients with epilepsy hepatic enzyme-inducing anti-epileptic drugs (AEDs) increase the metabolism of both progesterone and oestrogen. As the concentrations of these hormones may be lowered by 50% or more, adjustments are required in contraceptive regimes to ensure that pregnancy is prevented Initially, 50 mg/day PO administered in 2 divided doses. Increase the daily dose by 50 mg once per week during weeks 2, 3, and 4. Increase the daily dose by 100 mg once per week during weeks 5 and 6; administer total daily dose in 2 divided doses. One tablet contains 25 mg of topiramate. Excipients with known effect. Also includes lactose monohydrate: 25 mg tablet contains 30.85 mg lactose monohydrate. Topiramate 50mg Capsules, hard (Arrow) - Summary of Product Characteristics (SmPC) by Accord-UK Ltd Trokendi XR (topiramate) Extended-release Capsules. DESCRIPTION. Topiramate, USP, is a sulfamate-substituted monosaccharide. Trokendi XR™ (topiramate) extended-release capsules are available as 25 mg, 50 mg, 100 mg and 200 mg capsules for oral administration.